Key result
Tachycardia-induced heart failure blunts dobutamine-induced LV dP/dt max response by ~47%.
Why the study?
Left ventricular regional contraction alterations and regional inotropic reserve changes in tachycardia-induced heart failure were not well characterized.
Does tachycardia-induced heart failure alter regional inotropic reserve in conscious dogs?
Population
11 conscious dogs chronically instrumented to measure LV and atrial pressures and segmental contractions
Comparison
Tachycardia-induced heart failure vs control state
Design
Preclinical experimental study
Follow-up
3 weeks
Authors
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Heterogeneous regional LV dysfunction with uniform inotropic reserve loss in pacing HF; leaves open whether this pattern informs targeted therapies in patients.
Does tachycardia-induced heart failure alter regional inotropic reserve in conscious dogs?
Absolute Event Rate: 36% vs 68%
p-value: p=<0.01
In a canine model of tachycardia-induced heart failure, regional left ventricular contraction is heterogeneously depressed, but inotropic reserve is uniformly blunted across all regions.
Su et al. (1995) studied Tachycardia-induced heart failure (n=11). Tachycardia-induced heart failure vs. Control state was evaluated on Increase in LV dP/dt max during dobutamine infusion (15 micrograms/kg per min) (p=<0.01). In dogs with tachycardia-induced heart failure, dobutamine infusion increased LV dP/dt max less than in the control state (+36% vs +68%, P<0.01), though regional inotropic reserve was similarly modified.
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