What question did this study set out to answer?

This research aims to assess the impact of ventricular pacing on left ventricular function in dogs.

February 1, 1965American Journal of Physiology-Legacy Content

Hemodynamic alterations in left ventricular function consequent to ventricular pacing

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Why the study?

Does ventricular pacing alter left ventricular function compared to atrial pacing in mongrel dogs?

Population

Mongrel dogs

Comparison

Subendocardial electrical pacing from three left… vs Atrial pacing at constant heart rates

Design

Preclinical

Authors

JFJESSICA FINNEYUniversity of Technology Sydney

Discussion

Member takes

Implication

Highlights dyssynchrony risks in canine models; leaves open translation to clinical pacing decisions.

Key Points

This research aims to assess the impact of ventricular pacing on left ventricular function in dogs.
Mongrel dogs were used to evaluate left ventricular function through electrical pacing.
Electrical pacing was applied at three left ventricular sites and one right ventricular site.
Comparisons were made against atrial pacing at constant heart rates.
Left ventricular function significantly decreased with ventricular pacing (p < 0.01).
Maximal rate of tension development decreased more than the overall developed tension (p < 0.05).
Temporal dyssynergy of left ventricular contraction was identified as a key factor affecting function.

Structured PICO

Does ventricular pacing alter left ventricular function compared to atrial pacing in mongrel dogs?

Population

Mongrel dogs

Intervention

Subendocardial electrical pacing from three left ventricular sites and one right ventricular site (RVO)

Comparator

Atrial pacing at constant heart rates

Outcome

Left ventricular function (LVF) including left ventricular pressure, maximal rate of left ventricular pressure rise, cardiac output, stroke work, and stroke powersurrogate

Ventricular pacing significantly diminishes left ventricular function compared to atrial pacing, highlighting temporal dyssynergy as a key determinant of reduced function.

Cite This Study

JESSICA FINNEY (1965) studied this question.

synapsesocial.com/papers/6a11ccff1d1aaf8555562fcd https://doi.org/10.1152/ajplegacy.1965.208.2.275

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Hemodynamic alterations in left ventricular function consequent to ventricular pacing

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Hemodynamic alterations in left ventricular function consequent to ventricular pacing

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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