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November 1, 1971American Journal of Physiology-Legacy Content

Effects of altering ventricular rate on blood flow distribution in conscious dogs

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Why the study?

How do stepwise changes in ventricular rate affect systemic and regional blood flow distribution in conscious dogs with chronic AV block?

Population

8 conscious dogs with chronic atrioventricular block

Comparison

Stepwise changes in ventricular rate vs Different ventricular rates within the same…

Design

Preclinical

Authors

SWSUSAN L. WHITEUniversity of GeorgiaTPThomas PatrickUniversity of AlbertaCHCB HigginsUniversity of California, San Francisco

Discussion

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Implication

Hypothesis-generating for rate effects on regional flow in AV block models; leaves open translation to human pacing.

Structured PICO

How do stepwise changes in ventricular rate affect systemic and regional blood flow distribution in conscious dogs with chronic AV block?

P
Population
8 conscious dogs with chronic atrioventricular block
I
Intervention
Stepwise changes in ventricular rate (pacing from 40 to 220 beats/min and sudden cessation)
C
Comparator
Different ventricular rates within the same subjects
O
Outcome
Systemic arterial pressure, cardiac output, and regional blood flows (left circumflex coronary, mesenteric, renal, and external iliac arteries)surrogate

In conscious dogs with AV block, systemic hemodynamics are maintained between 110-180 bpm, but regional vascular beds exhibit differential flow responses to rate changes.

Cite This Study

WHITE et al. (1971) studied this question.

synapsesocial.com/papers/6a89b50aab4588dbccfb98b6https://doi.org/10.1152/ajplegacy.1971.221.5.1402
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Changing Heart Rate on Cardiovascular Function in the Conscious Dog1966 · 65 citations
  2. 2Coronary Hemodynamic Effects of Increasing Ventricular Rate in the Unanesthetized Dog1968 · 92 citations
  3. 3Influence of heart rate on left ventricular performance in conscious dogs.1987 · 129 citations
  4. 4Effects of pacing location on coronary circulation in dogs.1977 · 2 citations
  5. 5Long-term responses of atrial rate and peripheral resistance to changes in ventricular pacing rate in awake dogs with atrioventricular block.1984 · 3 citations