Why the study?
Does pacing-induced tachycardia alter regional left ventricular muscle blood flow in anaesthetized dogs?
Population
Anaesthetized dogs, including a model with an arteriovenous fistula
Comparison
Pacing-induced tachycardia (180 to 240 beats/min) vs Baseline heart rate (e.g., 120 beats/min)
Design
Preclinical
Authors
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Should not alter clinical pacing strategies; hypothesis-generating for subendocardial flow via diastolic driving pressure in tachycardia.
Does pacing-induced tachycardia alter regional left ventricular muscle blood flow in anaesthetized dogs?
In anaesthetized dogs, pacing-induced tachycardia increases coronary blood flow and can improve subendocardial blood flow in the presence of an arteriovenous fistula.
Buckberg et al. (1975) studied this question.
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