What question did this study set out to answer?

This study aims to investigate how varying ventricular rates affect cardiac output in dogs suffering from chronic heart block.

April 1, 1962Circulation ResearchOpen Access

Effect of Ventricular Rate on the Cardiac Output in the Dog with Chronic Heart Block

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Why the study?

Does alteration of ventricular rate affect cardiac output in dogs with chronic heart block?

Population

Dogs with chronic heart block

Design

Preclinical

Authors

DMDavid MillerAmerican University WGWilliam L. GleasonAmerican Heart Association RWRobert E. WhalenUnited States Department of Veterans Affairs

Discussion

Member takes

Implication

Cardiac output is rate-dependent in canine chronic heart block; leaves open optimal pacing targets in patients.

Key Points

This study aims to investigate how varying ventricular rates affect cardiac output in dogs suffering from chronic heart block.
Measured stroke volume and cardiac output at different heart rates in dogs with chronic heart block.
Conducted cinefluorography to assess ventricular filling dynamics.
At heart rates below 60/min, stroke volume remained constant, while cardiac output was rate-dependent.
Above 60/min, cardiac output decreased due to impaired diastolic filling despite elevated end-diastolic pressures.

Structured PICO

Does alteration of ventricular rate affect cardiac output in dogs with chronic heart block?

Population

Dogs with chronic heart block

Intervention

Alteration of ventricular rate

Outcome

Cardiac outputsurrogate

In a canine model of chronic heart block, cardiac output decreases at both very slow and very fast ventricular rates due to rate dependence and impaired diastolic filling, respectively.

Cite This Study

Miller et al. (1962) studied this question.

synapsesocial.com/papers/6a20ba22e19207255aa024f3 https://doi.org/10.1161/01.res.10.4.658

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Effect of Ventricular Rate on the Cardiac Output in the Dog with Chronic Heart Block

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of Ventricular Rate on the Cardiac Output in the Dog with Chronic Heart Block

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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