Why the study?
How do changes in inotropy and blood volume affect the optimal heart rate for maximal cardiac output during right atrial pacing in anaesthetized dogs?
How do changes in inotropy and blood volume affect the optimal heart rate for maximal cardiac output during right atrial pacing in anaesthetized dogs?
In a canine model, optimal heart rate for maximal cardiac output is determined by inotropy rather than blood volume and can be predicted from the linear relationship between stroke volume and heart rate.
Authors
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Should not guide clinical heart rate targets; leaves open translation of inotropy effects from canine models to humans.
Ilebekk et al. (1979) studied this question.
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