Population
Intact dog heart model (n=13 dogs, 161 extrasystolic sequences with compensatory pauses)
Comparison
Extrasystolic sequences with compensatory pauses vs Control cardiac cycles
Design
Preclinical
Authors
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Caution against clinical extrapolation from canine hearts; leaves open dominant mechanisms in human postextrasystolic potentiation.
In the intact dog heart, postextrasystolic potentiation augments stroke volume through a combination of intrinsic mechanisms, increased preload, and decreased afterload.
Yellin et al. (1979) studied this question.
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