Key result
Post-extrasystolic potentiation induced by an atrial extrasystole improved left ventricular function in both normal and diseased hearts, independent of the Frank-Starling mechanism.
Why the study?
Does an induced atrial extrasystole without a compensatory pause cause post-extrasystolic potentiation of left ventricular function in normal and diseased hearts?
Population
60 individuals, comprising 11 healthy individuals and 49 patients with coronary heart disease.
Comparison
Regularly driven right atrial rhythm interrupted… vs Pre-extrasystolic beats.
Design
Other
Authors
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May aid LV contractility assessment in catheterization; confirms intrinsic myocardial compensation beyond preload.
Does an induced atrial extrasystole without a compensatory pause cause post-extrasystolic potentiation of left ventricular function in normal and diseased hearts?
Post-extrasystolic potentiation occurs independently of the Frank-Starling mechanism in both normal and diseased hearts, suggesting it is an intrinsic compensating mechanism of the myocardium.
Kuijer et al. (1990) studied Coronary heart disease (n=60). Induction of post-extrasystolic potentiation via right atrial pacing vs. Pre-extrasystolic beats was evaluated on Indices of left ventricular function (ejection fraction, mean normalised systolic ejection rate, systolic volume, and stroke volume). Post-extrasystolic potentiation induced by an atrial extrasystole improved left ventricular function in both normal and diseased hearts, independent of the Frank-Starling mechanism.
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