Differing mechanisms of exercise flow augmentation at the mitral and aortic valves.
Key result
Exercise increased aortic flow via increased velocity-time integral (+15% supine, +48% upright), whereas mitral flow increased via increased cross-sectional area (+29% supine, +34% upright).
Why the study?
What are the differing mechanisms of exercise flow augmentation at the mitral and aortic valves in normal men?
Population
18 normal men
Comparison
Graded supine and upright bicycle exercise at… vs Rest (baseline)
Design
Cross-sectional
Authors
Discussion
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Implication
Highlights need for valve-specific flow metrics in exercise testing; leaves open translation to patients with cardiovascular disease.
Study Design
Type
Observational (n=18)
Structured PICO
What are the differing mechanisms of exercise flow augmentation at the mitral and aortic valves in normal men?
P
Population
18 normal men
I
Intervention
Graded supine and upright bicycle exercise at matched workloads
C
Comparator
Rest (baseline)
O
Outcome
Changes in cross-sectional area and velocity-time integral at the mitral and aortic valves measured by Doppler echocardiographysurrogate
Main Result
p-value: p=<0.05
Exercise-induced flow augmentation occurs via increased velocity at the aortic valve but via increased cross-sectional area at the mitral valve.
Cite This Study
Rassi et al. (1988) conducted an observational in Healthy volunteers (n=18). Graded supine and upright bicycle exercise vs. Rest was evaluated on Mechanisms of blood flow increase across mitral and aortic valves (p=<0.05). Exercise increased aortic flow via increased velocity-time integral (+15% supine, +48% upright), whereas mitral flow increased via increased cross-sectional area (+29% supine, +34% upright).