Why the study?
Does high-frequency pacing-induced demand ischemia alter early and late diastolic function in a canine model of stunned myocardium?
Population
10 anesthetized dogs instrumented with a micromanometer for left ventricular pressure and sonomicrometers…
Comparison
15 min of high-frequency pacing to induce demand… vs Measurements before pacing (baseline)
Design
Preclinical
Follow-up
3 minutes after the end of pacing
Authors
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May selectively impair early diastolic relaxation in stunned myocardium without affecting distensibility; leaves open translation to clinical settings.
Does high-frequency pacing-induced demand ischemia alter early and late diastolic function in a canine model of stunned myocardium?
In a canine model of stunned myocardium, early diastolic function is significantly impaired while late diastolic distensibility remains intact.
Miyazaki et al. (1993) studied this question.
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