Why the study?
Does chronic cardiac denervation alter regional ventricular function and stiffness responses to acute myocardial ischemia in conscious dogs?
Population
Conscious dogs
Comparison
Chronic cardiac denervation prior to acute… vs Intact cardiac innervation prior to acute…
Design
Preclinical
Authors
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Supports neural modulation of ischemic stiffness; hypothesis-generating in animals, clinical translation untested.
Does chronic cardiac denervation alter regional ventricular function and stiffness responses to acute myocardial ischemia in conscious dogs?
Cardiac innervation plays a significant role in modulating regional ventricular function and myocardial stiffness during acute myocardial ischemia.
Amano et al. (1987) studied this question.
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