Population
Anesthetized open-chest dogs (n=28)
Comparison
Demand-type ischemia vs Primary ischemia
Design
Preclinical
Follow-up
3 minutes
Authors
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Does not support clinical practice changes in ischemia; leaves open mechanistic distinctions in diastolic function pending human validation.
Demand-type ischemia and primary ischemia produce distinct metabolic and functional consequences, with demand ischemia uniquely decreasing diastolic distensibility despite a less severe reduction in tissue pH.
Momomura et al. (1985) studied this question.
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