Key Points
- To investigate changes in regional wall thickness and segment lengths in the left ventricle following coronary artery occlusion.
- Measured wall thickness and segment lengths using ultrasonic-dimension gauges in conscious dogs.
- Compared normal and ischemic zones before and after chronic circumflex artery occlusion.
- Assessed changes at 3 days and 3 weeks post-occlusion.
- In normal zones, end-diastolic segment lengths increased by 10% (P<0.01) and wall thickness decreased by 12.8% (P<0.01).
- In ischemic zones, end-diastolic segment lengths decreased by 15.4% (P<0.01), while systolic wall thickening improved to 38% of control at 3 weeks.
Structured PICO
IInterventionChronic circumflex artery occlusion
CComparatorBaseline measurements before occlusion and normal non-ischemic zones
OOutcomeRegional wall thickness and endocardial segment lengths measured simultaneously with ultrasonic-dimension gaugessurrogate
Recovery of function in the outer layers of the ventricular wall after myocardial infarction modifies the acute correlation between regional subendocardial segment and wall thickening dynamics.