Serial evaluation of myocardial thickening and thinning in acute experimental infarction: identification and quantification using two-dimensional echocardiography.
Why the study?
Does serial 2-D echocardiography accurately predict tissue infarct size in an experimental model of acute myocardial infarction?
Population
20 dogs after left anterior descending coronary artery ligation and 20 healthy dogs used to establish normal…
Comparison
Serial evaluation of regional left ventricular… vs Normal values established in healthy dogs
Design
Preclinical
Follow-up
48 hours
Authors
Discussion
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Member takes
Implication
Early ACS on echo should not guide infarct size estimates in AMI; leaves open serial imaging utility for tracking course in clinical settings.
Structured PICO
Does serial 2-D echocardiography accurately predict tissue infarct size in an experimental model of acute myocardial infarction?
P
Population
20 dogs after left anterior descending coronary artery ligation and 20 healthy dogs used to establish normal values
I
Intervention
Serial evaluation of regional left ventricular function by quantitative two-dimensional echocardiography at 2, 24, and 48 hours
C
Comparator
Normal values established in healthy dogs
O
Outcome
Correlation between abnormally contracting segments (ACS) by 2-D echocardiography and tissue infarct size at 48 hourssurrogate
In an experimental acute myocardial infarction model, abnormally contracting segments on 2-D echocardiography overestimate early infarct size and correlate only fairly with tissue necrosis at 48 hours, suggesting it is better for tracking infarction course than predicting infarct size.
Cite This Study
Nieminen et al. (1982) studied this question.