What question did this study set out to answer?

To evaluate the function of myocardium after acute coronary occlusion and subsequent treatment in dogs.

January 1, 1983CirculationOpen Access

Impaired function of salvaged myocardium: two-dimensional echocardiographic quantification of regional wall thickening in the open-chest dog.

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Why the study?

Does salvaged myocardium exhibit normal functional properties (systolic thickening) 7 days after acute coronary occlusion and drug treatment in a dog model?

Key Points

To evaluate the function of myocardium after acute coronary occlusion and subsequent treatment in dogs.
Ten conscious mongrel dogs underwent circumflex coronary occlusion followed by treatment with prostacyclin, ibuprofen, or dipyridamole.
Echocardiograms were performed 7 days post occlusion to quantify regional wall thickening.
Histological analysis was correlated with echocardiographic findings using a computer-aided contouring system.
Percent systolic thickening in the occluded bed was -4.5 +/- 3.1, significantly reduced compared to 28.6 +/- 4.7 in the nonischemic wall (p < 0.01).
Even segments with normal histology and blood flow showed 52% less thickening compared to nonischemic regions (p < 0.02).
Overall, despite minimal necrosis, myocardium remained functionally compromised post-occlusion.

Structured PICO

Does salvaged myocardium exhibit normal functional properties (systolic thickening) 7 days after acute coronary occlusion and drug treatment in a dog model?

Population

10 conscious mongrel dogs subjected to mild-circumflex coronary occlusion

Intervention

Treatment for 6 hours with prostacyclin (540 ng/kg/min) and ibuprofen (110 micrograms/kg/min), or dipyridamole (7-9.7 micrograms/kg/min)

Comparator

Nonischemic anterior wall (internal control)

Outcome

Percent systolic thickening assessed by cross-sectional two-dimensional echocardiography at 7 dayssurrogate

Salvaged myocardium remains functionally abnormal (stunned) with depressed systolic thickening 7 days after acute coronary occlusion, despite normal histology and restored blood flow.

Discussion

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Implication

Salvaged myocardium may remain stunned at 7 days despite normal flow; leaves open recovery timelines in human reperfusion.

Cite This Study

Blumenthal et al. (1983) studied this question.

synapsesocial.com/papers/6a20e48c34bef10fdaeb1bea https://doi.org/10.1161/01.cir.67.1.225

Topics

Echocardiography

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Impaired function of salvaged myocardium: two-dimensional echocardiographic quantification of regional wall thickening in the open-chest dog.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Impaired function of salvaged myocardium: two-dimensional echocardiographic quantification of regional wall thickening in the open-chest dog.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider