Impaired thickening of nonischemic myocardium during acute regional ischemia in the dog.
Key result
During transmural ischemia, percent systolic thickening decreased from 44.9% at baseline to -16.1% in the ischemic region and was also markedly impaired in adjacent nonischemic myocardium.
Population
18 open-chest anesthetized dogs
Comparison
Graded circumflex coronary arterial stenosis… vs Baseline state prior to ischemia
Design
Preclinical
Authors
Discussion
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Implication
Impaired thickening in nonischemic zones may overestimate ischemia extent; leaves open applicability to clinical imaging.
Structured PICO
P
Population
18 open-chest anesthetized dogs subjected to graded circumflex coronary arterial stenosis to study regional myocardial function.
I
Intervention
Graded circumflex coronary arterial stenosis (inducing regional ischemia), with subsets receiving dipyridamole (0.21 to 0.42 mg/min iv) or propranolol (0.1 mg/kg iv)
C
Comparator
Baseline state prior to ischemia
O
Outcome
Percent systolic thickening measured at 16 equally spaced points around the left ventricle by two-dimensional echocardiographysurrogate
Main Result
Absolute Event Rate: -16.1% vs 44.9%
During acute regional ischemia, systolic thickening is impaired in adjacent nonischemic myocardium, suggesting that functional dysfunction overestimates the true extent of ischemia due to mechanical tethering.
Cite This Study
Lima et al. (1985) studied Acute regional ischemia (n=18). Graded circumflex coronary arterial stenosis vs. Baseline was evaluated on Percent systolic thickening. During transmural ischemia, percent systolic thickening decreased from 44.9% at baseline to -16.1% in the ischemic region and was also markedly impaired in adjacent nonischemic myocardium.