Key result
Coronary occlusion and reperfusion in dogs caused significantly larger cross-sectional cell areas in the infarcted posterior wall compared to controls (e.g., 317 vs 233 µm² in subendocardium; p<0.05).
Why the study?
Does myocardial infarction followed by reperfusion induce myocardial cell hypertrophy in the ischemic zone in a canine model?
Does myocardial infarction followed by reperfusion induce myocardial cell hypertrophy in the ischemic zone in a canine model?
p-value: p=<0.05
In a canine model, myocardial infarction followed by reperfusion leads to significant cellular hypertrophy in both infarcted and noninfarcted zones, which may contribute to late recovery of regional function.
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Hypertrophy may aid late regional recovery after reperfusion; hypothesis-generating for human post-MI mechanisms.
Kambayashi et al. (1992) studied Myocardial infarction with reperfusion (n=14). Coronary artery occlusion followed by reperfusion vs. Control dogs without infarction was evaluated on Cross-sectional areas of surviving cells (p=<0.05). Coronary occlusion and reperfusion in dogs caused significantly larger cross-sectional cell areas in the infarcted posterior wall compared to controls (e.g., 317 vs 233 µm² in subendocardium; p<0.05).
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