Why the study?
Does arterial pressure elevation via methoxamine infusion produce different hemodynamic and echocardiographic responses in canines with preserved versus reduced ejection fraction?
Does arterial pressure elevation via methoxamine infusion produce different hemodynamic and echocardiographic responses in canines with preserved versus reduced ejection fraction?
In a canine model of chronic left ventricular dysfunction, acute pressure loading produced similar adverse hemodynamic and diastolic responses regardless of whether the baseline ejection fraction was preserved or reduced.
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Acute pressure loading yields EF-independent responses in canine LV dysfunction; hypothesis-generating and should not yet inform human HFpEF/HFrEF management.
Lavine et al. (2008) studied this question.
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