Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 1, 1990AJP Heart and Circulatory Physiology

Effects of increased afterload on left ventricular function in closed-chest dogs

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does increased afterload via balloon inflation alter left ventricular mechanical function in closed-chest dogs?

Population

6 closed-chest dogs chronically instrumented with three orthogonal diameter gauges and LV manometers…

Comparison

Balloon inflation in the proximal descending… vs Baseline (before balloon inflation)

Design

Preclinical

Authors

GFGregory L. FreemanUniversity of Connecticut

Discussion

Loading...

Member takes

Implication

Afterload elevation impairs LV efficiency in this canine model; leaves open translation to human HF energetics.

Structured PICO

Does increased afterload via balloon inflation alter left ventricular mechanical function in closed-chest dogs?

P
Population
6 closed-chest dogs chronically instrumented with three orthogonal diameter gauges and LV manometers, studied after autonomic blockade and fentanyl-droperidol anesthesia
I
Intervention
Balloon inflation in the proximal descending aorta to increase afterload
C
Comparator
Baseline (before balloon inflation)
O
Outcome
Left ventricular mechanical response including end-systolic pressure-volume (PES-VES) relations, stroke work end-diastolic volume (SW-EDV) relations, and pressure-volume area (PVA)surrogate

In an intact circulatory system, sustained increases in afterload alter left ventricular mechanical efficiency, decreasing the efficiency of energy transfer from pressure-volume area to stroke work.

Cite This Study

Gregory L. Freeman (1990) studied this question.

synapsesocial.com/papers/6a6f49c4e71d69abee07f0d3https://doi.org/10.1152/ajpheart.1990.259.2.h619
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of acutely increased right ventricular afterload on work output from the left ventricle in conscious dogs. Systolic ventricular interaction.1989 · 45 citations
  2. 2The effect of pericardium on the end-systolic pressure-segment length relationship in canine left ventricle in acute volume overload.1983 · 19 citations
  3. 3Effects of reduced resistive afterload on left ventricular pressure-volume relationship1985 · 9 citations
  4. 4Effect of Altered Resistive Load on Left Ventricular Systolic Mechanics in Dogs1982 · 18 citations
  5. 5Comparison of measures of left ventricular contractile performance derived from pressure-volume loops in conscious dogs.1989 · 214 citations