Key result
Reducing resistive load by opening peripheral arterio-venous shunts doubled mean ejection rate (P<0.01) and decreased left ventricular end-systolic volume (P<0.005) despite constant aortic pressure.
Why the study?
Does reducing resistive load improve left ventricular systolic mechanics in anesthetized dogs?
Population
14 anesthetized dogs pretreated with propranolol to block reflex changes in contractility
Comparison
Reducing resistive load by opening peripheral… vs Baseline conditions before opening the shunts
Design
Preclinical
Authors
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Does not inform clinical afterload strategies; extends experimental insights into LV ejection at constant pressure.
Does reducing resistive load improve left ventricular systolic mechanics in anesthetized dogs?
p-value: p=<0.01
Reducing resistive afterload allows the left ventricle to shorten further and faster during ejection even when aortic and left ventricular pressures remain constant.
Prewitt et al. (1982) studied this question. Reducing resistive load by opening peripheral arterio-venous shunts vs. Baseline conditions was evaluated on Mean ejection rate and left ventricular end-systolic volume (p=<0.01). Reducing resistive load by opening peripheral arterio-venous shunts doubled mean ejection rate (P<0.01) and decreased left ventricular end-systolic volume (P<0.005) despite constant aortic pressure.
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