What question did this study set out to answer?

To assess how progressive volume loading alters specific components of left ventricular diastolic function, including filling velocity, myocardial relaxation, and chamber compliance.

April 1, 1996HeartOpen Access

Effects of gradual volume loading on left ventricular diastolic function in dogs: implications for the optimisation of cardiac output.

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Why the study?

Does gradual volume loading alter left ventricular diastolic function in an anesthetized dog model?

Population

8 mongrel dogs, anaesthetised and mechanically ventilated with both the chest and the pericardium closed

Comparison

Gradual volume loading with physiological saline… vs Basal conditions

Design

Preclinical

Authors

JFJosé FragataNova Medical (United States)JAJosé Carlos AreiasUniversidade do Porto

Discussion

Member takes

Implication

Animal data on volume loading and diastolic function require validation; leaves open impact on clinical volume management strategies.

Key Points

To assess how progressive volume loading alters specific components of left ventricular diastolic function, including filling velocity, myocardial relaxation, and chamber compliance.
Eight anaesthetised and mechanically ventilated mongrel dogs with closed chest and pericardium received graded saline infusions of 5 ml/kg (VL5), 10 ml/kg (VL10), and 15 ml/kg (VL15), followed by isosorbide dinitrate infusion (10 g/kg/min).
Hemodynamics and transthoracic Doppler echocardiography were used to measure mitral E and A wave velocities, E/A ratio, E wave deceleration time, and isovolumic relaxation time across loading phases.
Low to moderate volume loads (VL5 and VL10) enhanced early diastolic filling and chamber compliance, increasing the mean (SD) E/A ratio from 1.95 (0.3) at baseline to 2.0 (0.27) at VL5 and 2.6 (0.3) at VL10 (P < 0.00005) with minimal rises in diastolic pressure.
Extreme volume loading (VL15) induced restrictive diastolic dysfunction, sharply reducing the E/A ratio from 2.6 (0.3) at VL10 to 0.8 (0.05) at VL15 (P < 0.00005), shortening deceleration time, and markedly increasing ventricular diastolic pressures.
Isovolumic relaxation time prolonged continuously across loading, and the restrictive filling defects induced by extreme volume expansion were rapidly reversed by isosorbide dinitrate.

Structured PICO

Does gradual volume loading alter left ventricular diastolic function in an anesthetized dog model?

Population

8 mongrel dogs, anaesthetised and mechanically ventilated with both the chest and the pericardium closed

Intervention

Gradual volume loading with physiological saline (5 ml/kg, 10 ml/kg, and 15 ml/kg) followed by infusion of isosorbide dinitrate (10 g/kg/min)

Comparator

Basal conditions

Outcome

Left ventricular diastolic function components (filling velocities, relaxation, and chamber compliance)surrogate

Small and moderate volume loads improve ventricular diastolic function, whereas extreme volume loads induce a restrictive pattern that can be reversed by isosorbide dinitrate.

Cite This Study

Fragata et al. (1996) studied this question.

synapsesocial.com/papers/6a76b6ba7ecc675f86adfdd0 https://doi.org/10.1136/hrt.75.4.352

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Effects of gradual volume loading on left ventricular diastolic function in dogs: implications for the optimisation of cardiac output.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effects of gradual volume loading on left ventricular diastolic function in dogs: implications for the optimisation of cardiac output.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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