Key result
Chronic volume overloading via an aortocaval shunt in dogs caused progressive increases in left ventricular end-diastolic pressure (9.7 to 18.9 mm Hg, P<0.01) and stiffness, which were partially reversible upon shunt closure.
Population
16 conscious dogs (9 experimental and 7 control animals)
Comparison
Surgically produced large infrarenal aortocaval… vs Control animals without shunt, and intra-animal…
Design
Preclinical
Follow-up
Mean 6.8 weeks postshunt, with observations up to 4 months…
Authors
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Hypothesis-generating for reversible diastolic changes in volume overload; requires human studies before clinical translation.
p-value: p=<0.01
Chronic volume overloading in normal dogs causes a progressive, partially reversible reduction in diastolic compliance and a rightward shift of the diastolic left ventricular pressure-dimension relation.
MCCULLAGH et al. (1972) studied Chronic volume overloading (n=16). Infrarenal aortocaval shunt vs. Control animals / early postshunt baseline was evaluated on Left ventricular end-diastolic pressure (LVEDP), size (LVEDD), and stiffness (p=<0.01). Chronic volume overloading via an aortocaval shunt in dogs caused progressive increases in left ventricular end-diastolic pressure (9.7 to 18.9 mm Hg, P<0.01) and stiffness, which were partially reversible upon shunt closure.
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