Population
10 normal conscious dogs
Comparison
Maximum angiotensin II infusion, volume load… vs Baseline control state
Design
Preclinical
Authors
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Animal data indicate preload limits stroke volume during acute pressure loading in normal hearts; leaves open translation to human disease states.
The study demonstrates that sizable preload and stroke volume reserves exist in normal resting dogs, and the descending limb of LV performance during pressure loading is due to inadequate venous return.
Lee et al. (1986) studied this question.
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