Why the study?
Does elevation of preload increase left ventricular end-diastolic diameter in conscious dogs?
Population
7 conscious dogs instrumented with ultrasonic D transducers and miniature LV pressure (P) gauges
Comparison
Elevation of preload by three techniques: 1)… vs Control state and open-chest, anesthetized dog…
Design
Preclinical
Authors
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Minimal LVEDD rise despite high LVEDP in conscious dogs cautions against routine preload assumptions in practice; leaves open Frank-Starling relevance in human disease models.
Does elevation of preload increase left ventricular end-diastolic diameter in conscious dogs?
The Frank-Starling mechanism is not a primary controlling mechanism in normal, conscious dogs at rest, as left ventricular end-diastolic diameter is near maximal and does not increase substantially with elevated preload.
Boettcher et al. (1978) studied this question.
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