Why the study?
Does the Frank-Starling mechanism compensate for stroke volume reduction during elevated blood pressure under conditions of low inotropy in dogs?
Population
Closed-chest and open-chest dogs with low inotropy induced by propranolol infusion
Comparison
Intravenous infusion of angiotensin to raise… vs Baseline blood pressure and blood volume
Design
Preclinical
Authors
Loading...
Hypothesis-generating for afterload management in low-inotropy states; extends canine Frank-Starling data but leaves open human translation.
Does the Frank-Starling mechanism compensate for stroke volume reduction during elevated blood pressure under conditions of low inotropy in dogs?
The Frank-Starling mechanism significantly compensates for stroke volume reduction during acute afterload increases in the setting of low inotropy.
Ilebekk et al. (1978) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: