Why the study?
Does the Frank-Starling mechanism compensate for stroke volume reduction during blood pressure elevation under low inotropy in dogs?
Population
Closed-chest and open-chest dogs under conditions of low inotropy induced by beta-adrenergic receptor…
Comparison
Elevation of systolic left ventricular pressure… vs Baseline blood pressure and blood volume before…
Design
Preclinical
Authors
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Supports Frank-Starling compensation for afterload effects under low inotropy; leaves open translation to human HF.
Does the Frank-Starling mechanism compensate for stroke volume reduction during blood pressure elevation under low inotropy in dogs?
Under conditions of low inotropy, the Frank-Starling mechanism significantly compensates for stroke volume reduction during blood pressure elevation and enhances the effect of blood volume expansion.
Ilebekk et al. (1978) studied this question.
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