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November 1, 1986Circulation

The effect of vasoactive agents on the left ventricular end-systolic pressure-volume relation in closed-chest dogs.

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Why the study?

Do vasoactive agents influence the left ventricular end-systolic pressure-volume relation in closed-chest dogs?

Population

16 closed-chest dogs instrumented with micromanometer pressure transducers and piezoelectric crystals…

Comparison

Infusion of vasopressors and then nitroprusside vs Control levels of blood pressure (baseline)

Design

Preclinical

Authors

GFGregory L. FreemanUniversity of ConnecticutWLWilliam C. LittleInterventional CardiologyRORobert A. O’RourkeCardiac Imaging

Discussion

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Implication

Vasoactive agents may alter ESPVR in dogs; challenges load-insensitivity assumption and leaves open human translation.

Structured PICO

Do vasoactive agents influence the left ventricular end-systolic pressure-volume relation in closed-chest dogs?

P
Population
16 closed-chest dogs instrumented with micromanometer pressure transducers and piezoelectric crystals, studied after autonomic blockade and sedation
I
Intervention
Infusion of vasopressors (methoxamine, n=6; angiotensin II, n=10) and then nitroprusside
C
Comparator
Control levels of blood pressure (baseline)
O
Outcome
Left ventricular end-systolic pressure-volume relation (slope and Vo)surrogate

Clinically used vasoactive drugs, such as angiotensin II and methoxamine, significantly alter the left ventricular end-systolic pressure-volume relation in closed-chest dogs, indicating that this measure is not entirely load-insensitive.

Cite This Study

Freeman et al. (1986) studied this question.

synapsesocial.com/papers/6a1d40dc28423f2ce504ebd9https://doi.org/10.1161/01.cir.74.5.1107
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of coronary perfusion and myocardial edema on pressure-volume diagram of left ventricle1961 · 133 citations
  2. 2Left ventricular systolic dynamics in terms of its chamber mechanical properties1983 · 61 citations
  3. 3End-systolic force-length relationship of nonexcised canine papillary muscle1977 · 24 citations
  4. 4Sensitivity of end-systolic pressure-dimension and pressure-volume relations to the inotropic state in humans.1982 · 217 citations
  5. 5Contractile state of the left ventricle in man as evaluated from end-systolic pressure-volume relations.1977 · 604 citations