What question did this study set out to answer?

To determine whether impaired endothelium-dependent vasodilation resolves concurrently with hemodynamic improvement following the cessation of pacing-induced congestive heart failure.

January 1, 1997Japanese Circulation Journal-english EditionOpen Access

The Delayed Recovery of Impaired Endothelium-Dependent Vasodilatory Response After Hemodynamic Improvement in Dogs With Congestive Heart Failure

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Why the study?

Does cessation of pacing and hemodynamic improvement restore endothelium-dependent vasodilatory response in dogs with pacing-induced congestive heart failure?

Population

Dogs with 2-week pacing-induced chronic congestive heart failure and control dogs with pacemaker implanted…

Comparison

Cessation of pacing to allow recovery for 1 week… vs Control group and active congestive heart…

Design

Preclinical

Follow-up

Up to 4 weeks after cessation of pacing

Authors

MUMasahiro UenoUniversity of Yamanashi SKSeinosuke KawashimaASKA Pharmaceutical (Japan)KIKiyomitsu IkeokaMidorigaoka Hospital

Discussion

Member takes

Implication

Endothelial recovery may lag hemodynamic improvement in experimental HF; leaves open translation to clinical management.

Key Points

To determine whether impaired endothelium-dependent vasodilation resolves concurrently with hemodynamic improvement following the cessation of pacing-induced congestive heart failure.
Evaluated 26 dogs across three groups: 2-week pacing-induced congestive heart failure (CHF, n = 12), recovery at 1 week (Re 1W, n = 6) or 4 weeks (Re 4W, n = 6) after pacing cessation, and sham control (n = 8).
Assessed echocardiographic and hemodynamic parameters alongside femoral blood flow responses to intra-arterial acetylcholine and nitroglycerin.
CHF caused elevated heart rate and pulmonary artery pressure, enlarged left ventricular diastolic dimension, and reduced percent fractional shortening, all of which returned to control levels by 1 week post-pacing.
Endothelium-independent vasodilation from nitroglycerin did not differ across groups, whereas acetylcholine-mediated vasodilatory responses were significantly reduced in CHF.
Femoral blood flow responses to acetylcholine remained impaired at 1 week of recovery despite normalized hemodynamics, returning to control levels only after 4 weeks of recovery.

Structured PICO

Does cessation of pacing and hemodynamic improvement restore endothelium-dependent vasodilatory response in dogs with pacing-induced congestive heart failure?

Population

Dogs with 2-week pacing-induced chronic congestive heart failure (n=12) and control dogs with pacemaker implanted without pacing (n=8)

Intervention

Cessation of pacing to allow recovery for 1 week (n=6) or 4 weeks (n=6)

Comparator

Control group (pacemaker implanted without pacing) and active congestive heart failure group

Outcome

Femoral blood flow responses to intra-arterial administration of nitroglycerin and acetylcholinesurrogate

Vascular endothelial dysfunction recovers after hemodynamic improvement in heart failure, but this recovery is delayed compared to the improvement in cardiac function.

Cite This Study

Ueno et al. (1997) studied this question.

synapsesocial.com/papers/6a90916ce73a4c404fc94dff https://doi.org/10.1253/jcj.61.936

Topics

Heart failure HFrEF treatment

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The Delayed Recovery of Impaired Endothelium-Dependent Vasodilatory Response After Hemodynamic Improvement in Dogs With Congestive Heart Failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

The Delayed Recovery of Impaired Endothelium-Dependent Vasodilatory Response After Hemodynamic Improvement in Dogs With Congestive Heart Failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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