Key result
Severe heart failure was associated with markedly impaired vasodilation to acetylcholine compared to normal controls (59% vs 586% increase in forearm blood flow; p<0.01).
Why the study?
Is the impairment of nitric oxide-mediated vasodilation related to the clinical severity of congestive heart failure?
Population
n=22 subjects, comprising 8 normal subjects, 6 patients with moderate heart failure, and 8 patients with…
Comparison
Local brachial infusion of acetylcholine… vs Comparisons between normal subjects, moderate…
Design
Cross-sectional
Authors
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Impaired endothelial function tracks HF severity; leaves open whether it drives progression or is modifiable.
Observational (n=22)
Is the impairment of nitric oxide-mediated vasodilation related to the clinical severity of congestive heart failure?
Absolute Event Rate: 59% vs 586%
p-value: p=<0.01
Vasodilator responses to acetylcholine and sodium nitroprusside are impaired in patients with heart failure, and this endothelial dysfunction correlates with the clinical severity of the disease.
Carville et al. (1998) conducted an observational in Congestive heart failure (n=22). Severe heart failure vs. Normal subjects was evaluated on Forearm blood flow (FBF) increase in response to 80 microg/min acetylcholine (p=<0.01). Severe heart failure was associated with markedly impaired vasodilation to acetylcholine compared to normal controls (59% vs 586% increase in forearm blood flow; p<0.01).
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