Key result
Elderly patients with chronic heart failure exhibited blunted vasodilator responses to sodium nitroprusside (13.7 vs 24.8 units, P<0.001) and acetylcholine (7.5 vs 24.8 units, P<0.001) versus controls.
Why the study?
Are endothelium-dependent and independent vasodilator responses impaired in elderly patients with chronic heart failure on modern medical management compared to controls?
Case-Control (n=39)
Are endothelium-dependent and independent vasodilator responses impaired in elderly patients with chronic heart failure on modern medical management compared to controls?
Absolute Event Rate: 13.7% vs 24.8%
p-value: p=<0.001
Endothelium-dependent and independent vasodilator responses remain blunted in elderly patients with chronic heart failure despite modern medical management.
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Impairment persists despite modern HF therapy; hypothesis-generating for targeted vascular interventions in elderly patients.
Morgan et al. (2004) conducted a case-control in Chronic heart failure (n=39). Chronic heart failure vs. Controls was evaluated on Forearm blood flow response to sodium nitroprusside (SNP) (p=<0.001). Elderly patients with chronic heart failure exhibited blunted vasodilator responses to sodium nitroprusside (13.7 vs 24.8 units, P<0.001) and acetylcholine (7.5 vs 24.8 units, P<0.001) versus controls.
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