Exercise-induced vasodilation in forearm circulation of normal subjects and patients with congestive heart failure: Role of endothelium-derived nitric oxide
Why the study?
Does regional inhibition of nitric oxide synthesis with L-NMMA alter exercise-induced forearm vasodilation in patients with congestive heart failure compared to normal subjects?
Population
17 patients with congestive heart failure and 10 age-matched normal subjects.
Comparison
Administration of L-NG-monomethylarginine in the… vs Before administration of L-NMMA and age-matched…
Design
Cross-sectional
Authors
Discussion
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Implication
Impaired nitric oxide-mediated exercise vasodilation in heart failure; hypothesis-generating for endothelial dysfunction as contributor to reduced capacity.
Structured PICO
Does regional inhibition of nitric oxide synthesis with L-NMMA alter exercise-induced forearm vasodilation in patients with congestive heart failure compared to normal subjects?
P
Population
17 patients with congestive heart failure (mean age 49 years, mean left ventricular ejection fraction 0.22) and 10 age-matched normal subjects.
I
Intervention
Administration of L-NG-monomethylarginine (L-NMMA) in the brachial artery during rhythmic hand grip exercise at 15%, 30% and 45% of maximal voluntary contraction.
C
Comparator
Before administration of L-NMMA (baseline) and age-matched normal subjects.
O
Outcome
Forearm blood flows (ml/min per 100 ml) determined by venous occlusion plethysmography.surrogate
Nitric oxide-mediated vasodilation during submaximal exercise is impaired in the forearm circulation of patients with congestive heart failure.
Cite This Study
Katz et al. (1996) studied this question.