The contribution of nitric oxide to exercise hyperemia in the human forearm
Why the study?
Does nitric oxide synthase inhibition with L-NMMA alter exercise-induced hyperemia in the human forearm?
Population
30 healthy participants (9 in L-NMMA group, 9 in L-NMMA + nitroprusside group, 12 in time-control group)
Comparison
Intra-arterial administration of the… vs Baseline measurements and a separate…
Design
Other
Follow-up
5 minutes post-exercise
Authors
Discussion
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Member takes
Implication
Should not alter exercise testing protocols; hypothesis-generating for NO's role in recovery-phase hyperemia.
Structured PICO
Does nitric oxide synthase inhibition with L-NMMA alter exercise-induced hyperemia in the human forearm?
P
Population
30 healthy participants (9 in L-NMMA group, 9 in L-NMMA + nitroprusside group, 12 in time-control group)
I
Intervention
Intra-arterial administration of the NOS-inhibitor NG-monomethyl-L-arginine (L-NMMA, 2 mg x min(-1)) with or without nitroprusside (0.2 microg x min(-1)) during wrist flexion exercise
C
Comparator
Baseline measurements (before administration) and a separate time-control group
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Outcome
Forearm blood flow (peak flow immediately after exercise and integrated post-exercise hyperemic volume) assessed with venous occlusion strain-gauge plethysmographysurrogate
Nitric oxide primarily regulates blood flow during the recovery period after dynamic exercise rather than determining peak limb blood flow immediately after exercise cessation.
Cite This Study
Gordon et al. (2002) studied this question.