Why the study?
Does perindopril improve Angiotensin I elimination and reduce myocardial damage in a rat model of myocardial injury?
Population
Male Wistar conscious rats with experimental myocardial injury induced by intracoronary microembolization
Comparison
Perindopril 2 mg/kg/day from days 2-20 after… vs Saline
Design
Preclinical
Follow-up
21 days
Authors
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Early perindopril may attenuate scarring in rat microembolization; leaves open translation to human post-MI therapy.
Does perindopril improve Angiotensin I elimination and reduce myocardial damage in a rat model of myocardial injury?
Early perindopril treatment prevents maladaptive changes in Angiotensin I processing and reduces myocardial tissue damage in a rat model of coronary microembolization.
Каленикова et al. (1998) studied this question.
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