Key result
Enalapril reduced mean arterial pressure in rats, but chronic administration increased plasma angiotensin II above normal, suggesting actions independent of plasma angiotensin II formation blockade.
Why the study?
Does enalapril reduce blood pressure dependently or independently of plasma angiotensin II levels in rats?
Does enalapril reduce blood pressure dependently or independently of plasma angiotensin II levels in rats?
The blood pressure-lowering effects of ACE inhibitors may occur independently of the blockade of plasma angiotensin II formation.
No takes yet. Share an insight, caveat, or question.
ACEI BP reduction may act independently of plasma Ang II in rats; hypothesis-generating for human mechanisms, no practice change.
Mento et al. (1987) studied Blood pressure regulation. Enalapril vs. Control was evaluated on Mean arterial pressure and plasma angiotensin II concentration. Enalapril reduced mean arterial pressure in rats, but chronic administration increased plasma angiotensin II above normal, suggesting actions independent of plasma angiotensin II formation blockade.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: