Why the study?
Does EXP3174 or enalaprilat reduce myocardial infarct size in a canine model of ischaemia-reperfusion?
Population
Anaesthetized dogs in a model of ischaemia-reperfusion
Comparison
EXP3174 or enalaprilat vs Saline
Design
Preclinical
Follow-up
5.5 hours
Authors
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No infarct size reduction by EXP3174 or enalaprilat in canine ischaemia-reperfusion; leaves open translation to other models or clinical settings.
Does EXP3174 or enalaprilat reduce myocardial infarct size in a canine model of ischaemia-reperfusion?
Inhibition of the renin-angiotensin system with EXP3174 or enalaprilat does not reduce myocardial infarct size in a canine model of ischaemia-reperfusion.
Richard et al. (1993) studied this question.
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