Why the study?
Do ACE inhibitors improve regional myocardial blood flow and reduce ischemic injury during coronary artery occlusion in dogs?
Population
Anesthetized dogs with intermittent coronary artery occlusion
Design
Preclinical
Authors
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No acute ischemic protection from ACE inhibitors in this canine model; leaves open human translation and requires further study.
Do ACE inhibitors improve regional myocardial blood flow and reduce ischemic injury during coronary artery occlusion in dogs?
In a canine model of coronary occlusion, ACE inhibitors did not improve regional myocardial blood flow or protect against ischemic injury despite reducing systemic blood pressure.
Berdeaux et al. (1987) studied this question.
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