Key result
In dogs with acute coronary occlusion, teprotide and captopril decreased peripheral vascular resistance and mean aortic pressure (p<0.05), but did not change infarct size.
Why the study?
Does renin-angiotensin system inhibition improve systemic hemodynamics and reduce infarct size in a canine model of acute myocardial infarction?
Population
21 conscious, chronically instrumented dogs with acute left anterior descending coronary artery occlusion
Comparison
i.v. teprotide, 25 micrograms/kg/min, followed… vs Saline-infused controls (n=12)
Design
Preclinical
Follow-up
24 hours
Authors
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ACE inhibition improves post-occlusion hemodynamics without altering infarct size or myocardial function; leaves open translation to human acute MI.
Does renin-angiotensin system inhibition improve systemic hemodynamics and reduce infarct size in a canine model of acute myocardial infarction?
p-value: p=<0.05
In a canine model of acute myocardial infarction, renin-angiotensin system inhibition improved systemic hemodynamics but did not directly affect myocardial blood flow, mechanics, or infarct size.
Liang et al. (1982) studied Acute myocardial infarction (n=21). Teprotide and captopril vs. Saline was evaluated on Peripheral vascular resistance, mean aortic pressure, cardiac output, and infarct size (p=<0.05). In dogs with acute coronary occlusion, teprotide and captopril decreased peripheral vascular resistance and mean aortic pressure (p<0.05), but did not change infarct size.
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