August 15, 1995Circulation
Beneficial Effects of Inhibition of Angiotensin-Converting Enzyme on Ischemic Myocardium During Coronary Hypoperfusion in Dogs
Why the study?
Does cilazaprilat improve coronary blood flow and myocardial function in a dog model of coronary hypoperfusion?
Population
65 open-chest dogs with left anterior descending coronary artery perfused through an extracorporeal bypass…
Comparison
Cilazaprilat infused into the bypass tube for 10… vs Untreated condition and conditions with…
Design
Preclinical
Follow-up
10 minutes
Authors
Discussion
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Implication
Supports ACE inhibition in canine ischemia; leaves open translation to human coronary disease.
Structured PICO
Does cilazaprilat improve coronary blood flow and myocardial function in a dog model of coronary hypoperfusion?
P
Population
65 open-chest dogs with left anterior descending coronary artery perfused through an extracorporeal bypass tube with partial occlusion to induce coronary hypoperfusion
I
Intervention
Cilazaprilat (3 micrograms/kg per minute) infused into the bypass tube for 10 minutes
C
Comparator
Untreated condition (baseline) and conditions with bradykinin, nitric oxide synthase, or angiotensin II receptor inhibitors (HOE-140, L-NAME, CV11974)
O
Outcome
Coronary blood flow, fractional shortening, and lactate extraction ratiosurrogate
ACE inhibition improves coronary blood flow and myocardial function during ischemia in dogs, primarily through bradykinin accumulation and nitric oxide production.
Cite This Study
Kitakaze et al. (1995) studied this question.