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February 1, 1990Journal of Cardiovascular Pharmacology

ACE Inhibition with Cilazapril Improves Myocardial Perfusion to the Ischemic Regions During Exercise

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Why the study?

Does cilazapril improve regional myocardial perfusion during exercise in patients with coronary heart disease and stable exertional angina?

Population

n=8 patients with documented coronary heart disease (CHD) and stable exertional angina

Comparison

Cilazapril 5 mg vs Placebo (each patient served as his own control)

Design

Other, nonrandomized, single-blind

Authors

SGS. GasićRoche (Switzerland)RDRobert DudczakMedical University of ViennaAKA. KornUniversity of Vienna

Discussion

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Implication

Cilazapril may enhance regional perfusion and relieve symptoms in stable angina; hypothesis-generating and requires randomized confirmation.

Structured PICO

Does cilazapril improve regional myocardial perfusion during exercise in patients with coronary heart disease and stable exertional angina?

P
Population
n=8 patients with documented coronary heart disease (CHD) and stable exertional angina
I
Intervention
Cilazapril 5 mg
C
Comparator
Placebo (each patient served as his own control)
O
Outcome
Percent myocardial activity differences (%AD) between exercise and resting images using [99mTc]hexakis-2-methoxy-2-isobutylisonitrile myocardial imagingsurrogate

In a small nonrandomized study, cilazapril improved regional myocardial perfusion and alleviated symptoms during exercise in patients with stable angina.

Cite This Study

Gasić et al. (1990) studied this question.

synapsesocial.com/papers/6a7f4e8acb1625f75919449ahttps://doi.org/10.1097/00005344-199002000-00008
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Beneficial Effects of Inhibition of Angiotensin-Converting Enzyme on Ischemic Myocardium During Coronary Hypoperfusion in Dogs1995 · 90 citations
  2. 2Influence of angiotensin converting enzyme inhibition on exercise performance and clinical symptoms in chronic heart failure: a multicentre, double-blind, placebo-controlled trial1993 · 24 citations
  3. 3The Effects of Cilazapril on Left Ventricular Remodeling after Coronary Intervention in Patients with Ischemic Heart Failure1998 · 2 citations
  4. 4Does the new angiotensin converting enzyme inhibitor cilazapril prevent restenosis after percutaneous transluminal coronary angioplasty? Results of the MERCATOR study: a multicenter, randomized, double-blind placebo-controlled trial. Multicenter European Research Trial with Cilazapril after Angioplasty to Prevent Transluminal Coronary Obstruction and Restenosis (MERCATOR) Study Group.1992 · 544 citations
  5. 5The effects of the long-acting angiotensin–converting enzyme inhibitor cilazapril on casual, exercise, and ambulatory blood pressure1988 · 19 citations