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July 2, 1993European Heart Journal

Influence of angiotensin converting enzyme inhibition on exercise performance and clinical symptoms in chronic heart failure: a multicentre, double-blind, placebo-controlled trial

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Why the study?

Does cilazapril improve exercise tolerance and clinical status in patients with chronic heart failure stabilized on digitalis and/or diuretics?

Population

107 patients with chronic heart failure stabilized on digitalis and/or diuretics, recruited from 11 centres.

Comparison

Cilazapril 1 mg daily starting dose, titrated to… vs Matching placebo for 12 weeks.

Design

RCT, Randomized, Double-blind, placebo-controlled

Follow-up

12 weeks

Authors

LDL. DösseggerRoche (Switzerland)EAE AldorHanusch HospitalMBM. G. BairdUniversity of Ottawa

Discussion

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Implication

Supports cilazapril addition to digitalis/diuretics for improved exercise tolerance in chronic HF; confirms ACE inhibitor benefit on functional status.

Structured PICO

Does cilazapril improve exercise tolerance and clinical status in patients with chronic heart failure stabilized on digitalis and/or diuretics?

P
Population
107 patients with chronic heart failure (NYHA class II to IV) stabilized on digitalis and/or diuretics, recruited from 11 centres.
I
Intervention
Cilazapril 1 mg daily starting dose, titrated to 2.5 mg at week 4 and 5 mg at week 8 if not improved clinically, for 12 weeks.
C
Comparator
Matching placebo for 12 weeks.
O
Outcome
Exercise tolerance (exercise test duration) and clinical status at 12 weeks.surrogate

In patients with chronic heart failure on standard therapy, the addition of the ACE inhibitor cilazapril significantly improves exercise tolerance and clinical symptoms.

Cite This Study

Dössegger et al. (1993) studied this question.

synapsesocial.com/papers/6a91a7e9ba3535a4ddf59358https://doi.org/10.1093/eurheartj/14.suppl_c.18
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of the Effects of Cilazapril and Captopril versus Placebo on Exercise Testing in Chronic Heart Failure Patients: A Double-Blind, Randomized, Multicenter Tria2008 · 12 citations
  2. 2The effects of the long-acting angiotensin–converting enzyme inhibitor cilazapril on casual, exercise, and ambulatory blood pressure1988 · 19 citations
  3. 3ACE Inhibition with Cilazapril Improves Myocardial Perfusion to the Ischemic Regions During Exercise1990 · 29 citations
  4. 4The Effects of Cilazapril on Left Ventricular Remodeling after Coronary Intervention in Patients with Ischemic Heart Failure1998 · 2 citations
  5. 5Quality of life in chronic heart failure: cilazapril and captopril versus placebo1998 · 12 citations