The Effects of ACE Inhibitors on Exercise Capacity in the Treatment of Congestive Heart Failure

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Why the study?

Does quinapril improve exercise time and NYHA functional class in patients with mild to moderate congestive heart failure?

Structured PICO

Does quinapril improve exercise time and NYHA functional class in patients with mild to moderate congestive heart failure?

Population

225 patients with mild to moderate congestive heart failure (CHF) due to arterial hypertension and ischemic heart disease

Intervention

Quinapril 5 mg, 10 mg, or 20 mg twice daily added to maintenance therapy with digitalis and/or diuretics for 12 weeks

Comparator

Placebo added to maintenance therapy with digitalis and/or diuretics

Outcome

Exercise time and NYHA functional classsurrogate

Quinapril significantly improves exercise capacity and functional status in patients with mild to moderate congestive heart failure.

No takes yet. Share an insight, caveat, or question.

Supports quinapril in mild-moderate HF; extends ACEI evidence for functional outcomes.

Günter A.J. Riegger (1990) studied this question.

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