Key result
Quinapril significantly increased exercise duration in CHF patients who exhibited a greater decrease in pulmonary versus systemic vascular resistance (+29% vs +7%, p<0.001).
Why the study?
Does quinapril improve exercise capacity in patients with mild to moderate congestive heart failure?
Cohort (n=22)
Does quinapril improve exercise capacity in patients with mild to moderate congestive heart failure?
Absolute Event Rate: 29% vs 7%
p-value: p=<0.001
ACE inhibitors improve exercise capacity predominantly in CHF patients with abnormal pulmonary hemodynamics, suggesting that effects on the pulmonary vasculature are a clinically important mechanism of benefit.
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Supports pulmonary hemodynamic response as predictor of ACEI exercise benefit in CHF; hypothesis-generating and requires prospective validation before guiding therapy.
Pelliccia et al. (1993) conducted a cohort in Mild to moderate congestive heart failure (n=22). Quinapril vs. Patients with %ΔPVR/%ΔSVR < 1 (Group B) was evaluated on Exercise duration (p=<0.001). Quinapril significantly increased exercise duration in CHF patients who exhibited a greater decrease in pulmonary versus systemic vascular resistance (+29% vs +7%, p<0.001).
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