Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 1989CirculationOpen Access

Contrasting peripheral short-term and long-term effects of converting enzyme inhibition in patients with congestive heart failure. A double-blind, placebo-controlled trial.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does cilazapril improve peripheral hemodynamics and oxygen utilization during exercise in patients with chronic heart failure?

Population

21 patients with chronic heart failure (17 completed the 3-month treatment)

Comparison

Cilazapril for 3 months vs Placebo for 3 months

Design

RCT, randomized, double-blind, placebo-controlled

Follow-up

3 months

Authors

HDHelmut DrexlerGoethe University FrankfurtUBUlrich BanhardtUniversity of FreiburgTMT. MeinertzDeutsche Herzstiftung

Discussion

Loading...

Member takes

Overview

Supports ACE inhibitor use to improve exercise capacity in chronic heart failure; confirms peripheral hemodynamic and oxygen utilization benefits.

Key Points

  • The study aimed to uncover the mechanisms of long-term benefits of ACE inhibitors in chronic heart failure patients.
  • Double-blind, placebo-controlled trial with 21 randomized patients.
  • Treatment with cilazapril over 3 months to assess hemodynamic and peripheral effects.
  • Evaluation of femoral blood flow, oxygen saturation, norepinephrine levels, and lactate during exercise.
  • Short-term ACE inhibition improved central hemodynamic output but not peak femoral blood flow.
  • Long-term ACE inhibition increased leg blood flow (from 2.3 to 2.9 l/min, p<0.05) and leg oxygen consumption (from 277 to 403 ml/min, p<0.05).
  • A significant increase in femoral oxygen extraction was observed post long-term therapy (76% to 83%, p<0.05), compared to placebo.

Structured PICO

Does cilazapril improve peripheral hemodynamics and oxygen utilization during exercise in patients with chronic heart failure?

P
Population
21 patients with chronic heart failure (17 completed the 3-month treatment)
I
Intervention
Cilazapril (long-acting ACE inhibitor) for 3 months
C
Comparator
Placebo for 3 months
O
Outcome
Central hemodynamic output, femoral blood flow, oxygen saturation, and lactate and norepinephrine levels determined simultaneously in the femoral vein and radial artery during rest and symptom-limited bicycle exercisesurrogate

Long-term ACE inhibition in heart failure improves exercise capacity by enhancing peripheral blood flow and skeletal muscle oxygen utilization.

Cite This Study

Drexler et al. (1989) studied this question.

synapsesocial.com/papers/6a1fe10dfd96d06e05430dbehttps://doi.org/10.1161/01.cir.79.3.491

Topics

HFrEF treatmentHeart failure
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute regional circulatory and renal hemodynamic effects of converting-enzyme inhibition in patients with congestive heart failure.1981 · 178 citations
  2. 2A comparison of the effects of vasodilator stimuli on peripheral resistance vessels in normal subjects and in patients with congestive heart failure1968 · 359 citations
  3. 3Biological Properties of the Angiotensin-Converting Enzyme Inhibitor Cilazapril1985 · 72 citations
  4. 4Failure to augment maximal limb blood flow in response to one-leg versus two-leg exercise in patients with severe heart failure.1986 · 231 citations
  5. 5Vascular wall renin in spontaneously hypertensive rats. Potential relevance to hypertension maintenance and antihypertensive effect of captopril.1982 · 143 citations