Why the study?
Do ACE inhibitors improve exercise duration in patients with symptomatic left ventricular systolic dysfunction?
Population
Patients with symptomatic left ventricular systolic dysfunction, 94% in NYHA class II-IV
Comparison
Angiotensin-converting enzyme inhibitors over… vs Placebo
Design
Meta-analysis, parallel group trials, double blind
Follow-up
4-12 weeks
Authors
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ACE inhibitors confer statistically significant yet modest exercise gains in symptomatic LVSD; confirms limited functional benefit on top of established outcomes.
Do ACE inhibitors improve exercise duration in patients with symptomatic left ventricular systolic dysfunction?
ACE inhibitors provide a statistically significant but clinically modest improvement in exercise duration (up to 30 seconds or 5%) in patients with symptomatic LVSD.
Abdulla et al. (2004) studied this question.
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