December 1, 1992Circulation
Angiotensin converting enzyme inhibition restores cardiac and hormonal responses to volume overload in patients with dilated cardiomyopathy and mild heart failure.
Why the study?
Does ACE inhibition with quinapril improve hemodynamic and hormonal responses to acute volume expansion in patients with dilated cardiomyopathy and mild heart failure?
Population
32 patients with idiopathic or ischemic dilated cardiomyopathy and mild heart failure.
Comparison
Oral ACE inhibitor quinapril 10 mg/day for 1… vs No pretreatment prior to acute volume expansion.
Design
Cohort
Follow-up
1 week
Authors
Discussion
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Member takes
Implication
May support quinapril pretreatment to preserve EF during volume expansion in mild HF; hypothesis-generating and should not yet change practice.
Structured PICO
Does ACE inhibition with quinapril improve hemodynamic and hormonal responses to acute volume expansion in patients with dilated cardiomyopathy and mild heart failure?
P
Population
32 patients with idiopathic or ischemic dilated cardiomyopathy and mild heart failure (NYHA class I or II, ejection fraction <= 50%).
I
Intervention
Oral ACE inhibitor quinapril 10 mg/day for 1 week (n=11) or constant intravenous infusion with nitroglycerin 0.1 micrograms/kg/min (n=7), followed by acute volume expansion (sodium chloride, 0.9%, 0.25 ml/kg/min for 2 hours).
C
Comparator
No pretreatment (n=14) prior to acute volume expansion.
O
Outcome
Hemodynamic, hormonal, and renal responses to acute volume expansion.surrogate
ACE inhibition with quinapril restores normal cardiovascular and hormonal responses to acute volume overload in patients with mild heart failure, likely due to cardiac unloading.
Cite This Study
Volpe et al. (1992) studied this question.