Why the study?
Does a single dose of quinapril 2.5 mg oral reduce blood pressure and inhibit ACE activity in elderly patients with stable, chronic congestive heart failure?
Population
n=24 elderly patients with stable, chronic congestive heart failure, NYHA II-IV, requiring addition of an…
Comparison
Single dose of quinapril 2.5 mg oral after 24-48… vs Matching placebo after 24-48 h supervised…
Design
RCT, randomised, double-blind
Follow-up
24 h
Authors
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Supports low-dose quinapril initiation in elderly stable HF; extends ACE inhibitor data to this population.
Does a single dose of quinapril 2.5 mg oral reduce blood pressure and inhibit ACE activity in elderly patients with stable, chronic congestive heart failure?
A single 2.5 mg oral dose of quinapril provides sustained ACE inhibition and moderate, well-tolerated blood pressure reduction for at least 10 hours in elderly patients with stable heart failure.
Squire et al. (1994) studied this question.
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