What question did this study set out to answer?

To review the efficacy and safety of quinapril, a new ACE inhibitor, in treating hypertension and congestive heart failure.

January 1, 1990Journal of Cardiovascular Pharmacology

Overview of Quinapril, A New ACE Inhibitor

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Why the study?

Is quinapril effective and safe compared to other ACE inhibitors or placebo in patients with hypertension or congestive heart failure?

Population

Patients with hypertension or congestive heart failure in the United States and Europe.

Comparison

Quinapril administered as monotherapy or in… vs Placebo, enalapril, captopril, chlorthalidone…

Design

Review, double-blind (in some included trials)

Follow-up

up to 3 years

Authors

GFGraham J. FrankWarde Medical Laboratory LKLloyd KnappPfizer (United States)SOStephen C. OlsonUnivates

Discussion

Member takes

Implication

Supports quinapril preference for tolerability in hypertension or HF; leaves open updated RCTs against modern comparators.

Key Points

To review the efficacy and safety of quinapril, a new ACE inhibitor, in treating hypertension and congestive heart failure.
Thirty-nine pharmacology studies with 383 patients assessed quinapril's effects.
Conducted 12 controlled, multicenter studies with 1,793 patients for hypertension.
Safety evaluated in 2,700 patients, with over 1,600 patient-years of exposure in double-blind studies.
Quinapril shows comparable efficacy to other ACE inhibitors, such as captopril and enalapril.
Lower incidence of adverse events during treatment compared to captopril or enalapril.
Over half of patients participated in long-term trials, revealing positive safety profiles.

Structured PICO

Is quinapril effective and safe compared to other ACE inhibitors or placebo in patients with hypertension or congestive heart failure?

Population

Patients with hypertension or congestive heart failure (CHF) in the United States and Europe (safety evaluated in almost 2,700 patients, including 451 aged ≥65 years).

Intervention

Quinapril (ACE inhibitor) administered as monotherapy or in addition to a diuretic, once or twice daily.

Comparator

Placebo, enalapril, captopril, chlorthalidone, or other comparative agents.

Outcome

Efficacy and safety (incidence of adverse events or withdrawals due to adverse events).safety

Quinapril is an effective ACE inhibitor for hypertension and heart failure with a favorable safety profile compared to older agents like captopril and enalapril.

Cite This Study

Frank et al. (1990) studied this question.

synapsesocial.com/papers/6a70462a87f921057127922d https://doi.org/10.1097/00005344-199000152-00004

Topics

Hypertension management HFrEF treatment Heart failure

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Overview of Quinapril, A New ACE Inhibitor

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Overview of Quinapril, A New ACE Inhibitor

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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