Why the study?
Does quinapril improve the safety profile compared to captopril or enalapril in patients with hypertension and congestive heart failure?
Population
3,031 patients with hypertension and congestive heart failure (CHF)
Comparison
Quinapril vs Other ACE inhibitors (captopril or enalapril)
Design
Review
Authors
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May support preferring quinapril for tolerability in hypertension or HF; leaves open need for randomized confirmation in contemporary practice.
Does quinapril improve the safety profile compared to captopril or enalapril in patients with hypertension and congestive heart failure?
Quinapril appears to have a favorable safety profile with fewer adverse effects and withdrawals compared to older ACE inhibitors like captopril and enalapril.
Canter et al. (2009) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: