What question did this study set out to answer?

To review the preclinical pharmacological, pharmacokinetic, and toxicological properties of the nonpeptide ACE inhibitor quinapril.

September 30, 2009Clinical Cardiology

Quinapril: Overview of preclinical data

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Population

In vitro and in vivo animal models including rabbit aorta, rats, spontaneously hypertensive rats, one-kidney…

Design

Review

Authors

HKHarvey KaplanCanadian Forest Service DTD G TaylorThe Tavistock and Portman NHS Foundation Trust SOS.C. OlsonThe University of Texas at Austin

Discussion

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Implication

Quinapril shows preclinical BP-lowering and LV-protective effects; leaves open translation to human hypertension or heart failure.

Key Points

To review the preclinical pharmacological, pharmacokinetic, and toxicological properties of the nonpeptide ACE inhibitor quinapril.
Assessed in vitro vascular contractile responses in rabbit aorta and in vivo blood pressure effects across spontaneously hypertensive rats, high-renin rodents, DOCA-salt rats, and diuretic-treated dogs.
Evaluated left ventricular contractile function in cardiomyopathic hamsters, measured tissue distribution and metabolic conversion to quinaprilat, and completed standard long-term toxicology assays.
Quinapril inhibited angiotensin I pressor responses and lowered blood pressure in renin-dependent models without induction of 14-day tolerance, correlating strongly with vascular tissue ACE inhibition.
Prevented the progressive decline of left ventricular contractile function in cardiomyopathic hamsters while maintaining a lipid-neutral metabolic profile.
Underwent rapid absorption and hydrolysis to the active diacid quinaprilat with extensive peripheral distribution and no evidence of mutagenic, teratogenic, or carcinogenic toxicity.

Structured PICO

Population

In vitro and in vivo animal models including rabbit aorta, rats, spontaneously hypertensive rats, one-kidney DOCA-salt hypertensive rat, diuretic-treated dog models, and cardiomyopathic hamsters

Intervention

Quinapril

Outcome

Blood pressure reduction, inhibition of tissue ACE, and left ventricular contractile functionsurrogate

Preclinical data demonstrate that quinapril is an effective ACE inhibitor that lowers blood pressure and may prevent the progression of left ventricular failure.

Cite This Study

Kaplan et al. (2009) studied this question.

synapsesocial.com/papers/6a7048d8439bab0cabc31992 https://doi.org/10.1002/clc.4960131403

Topics

Hypertension management

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Quinapril: Overview of preclinical data

Discussion

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Implication

Key Points

Structured PICO

Cite This Study

Topics

Quinapril: Overview of preclinical data

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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