Key result
Quinapril administration (0.3 mg/kg) in rats resulted in prolonged ACE inhibition, maintaining >40% inhibition in cardiac atria and ventricles at 24 hours.
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May guide cardiac tissue studies; leaves open human translation from this rat model.
Fabris et al. (1990) studied this question. Quinapril was evaluated on ACE inhibition in plasma and tissue. Quinapril administration (0.3 mg/kg) in rats resulted in prolonged ACE inhibition, maintaining >40% inhibition in cardiac atria and ventricles at 24 hours.
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